Chassis Mt4 #1116-1123 and Tipo F2 #2001, 2002 are produced during 1952
- April - OSCA ships first cars to the USA through its agent in Chicago, Edgard Fronteras. #1112 is shipped to the East Coast, #1122 to the West Coast.
- May 4th– 1952 Mille Miglia, OSCA scores 1st, 2nd, 3rd in class (1100 Sport)
- May 24th – Bridgehampton, First OSCA win in the USA. Frank Bott (#1112)
- June 1st– G.P. Di Monte Carlo (in 1952 run as a up to 2 liter sports car race), Bordoni places 2nd OA, driving his 1350cc Mt4 (#1117)
- June 29th – Targa Florio Sicily, Cabianca leads the OA race in his Mt4 during 6 out of the 8 laps, only to break an axle shaft and retire
- July - A single seater for the F2 category is designed featuring an inline six cylinder, twin cam engine with 170CV at 6500. A transaxle with a De Dion rear is used. Curb weight of 750kg.
- July - The iconic OSCA barchetta shape is designed in house. Bodies are produced by coachbuilders Vignale and Frua along with in-house craftsmen.
- Cabianca wins the Italian Championship (1100 Sport)